The commonality between science and art is in trying to see profoundly - to develop strategies of seeing and showing.

The daily act of writing remains as demanding and maddening as it was before and the pleasure you get from writing - rare but profound - remains at the true heart of the enterprise. On their best days writers all over the world are winning Pulitzers all alone in their studios with no one watching.

Solitude is the profoundest fact of the human condition. Man is the only being who knows he is alone.

About the time I turned 50 I experienced the profound biological change that often accompanies women at that age. Also I put two kids in college and lost both of my parents so I'm no longer somebody's daughter.

He has a profound respect for old age. Especially when it's bottled.